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CHOICE OF MINT,PINEAPPLE AND ORANGE. KAMAGRA Oral Jelly is a brand name for Ajanta's Sildenafil Citrate Oral Jelly.The product is in the jelly form, meant to be consumed orally and should be allowed to dissolve in the oral cavity before it is swallowed. KAMAGRA Oral Jelly More easily swallowed than tablets and therefore suitable for elderly people and also people who have difficulty in swallowing. Buccal cavity absorption, bypassing the hepatic metabolism thus leading to faster systemic circulation and faster onset of action. Reduced gastric irritation compared to tablets. Pleasant peppermint flavour. COMPOSITION: Each 5 gm contains: Sildenafil Citrate equivalent to Sildenafil 50 mg/100 mg MECHANISM OF ACTION: The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP) producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but enhances the effect of NO (Nitric oxide) by inhibiting phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increased levels of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavemosum. Studies invitro have shown that Sildenafil isselective for PDE5.Sildenafil at recommended doses has no effect in the absence of sexual stimulation.Sildenafil is not an aphrodisiac and does not increase sexual desire or fertility. INDICATIONS: KAMAGRA Oral Jelly is a potential oral therapy for the treatment of Erectile Dysfunction. Also useful in Antidepressant induced Sexual Dysfunction. DOSAGE: Contents of 1 sachet to be consumed approximately 20 minutes before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg. The maximum recommended dosing frequency is once per day. PRECAUTIONS AND WARNINGS: Not recommended for persons allergic to Sildenafil. Angina patients consuming nitrates and other Anti-anginal drugs may use Sildenafil only under Medical supervision and advice. Medical supervision is also required for patients who are under Cimetidine, Erythromycin, and Ketoconazole. Persons using any other MED drug must inform the Physician before using Sildenafil. To be used with caution in people with liver and kidney impairment. SIDE EFFECTS: Headache, flushing, dyspepsia, dizziness, nasal congestion and blurring of vision. PRESENTATION: In sachets of 5 gms.

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